Preparation, purification and regioselective functionalization of protoescigenin--the main aglycone of escin complex.
نویسندگان
چکیده
A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture--protoescigenin--was isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic methods. This material was further converted into the high purity 3,24;16,22-di-O,O-isopropylidene derivative in a validated large scale laboratory process.
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عنوان ژورنال:
- Molecules
دوره 18 4 شماره
صفحات -
تاریخ انتشار 2013